The spanish influenza pandemic: a lesson from history 100 years after 1918

In Europe in 1918, influenza spread through Spain, France, Great Britain and Italy, causing havoc with military operations during the First World War. The influenza pandemic of 1918 killed more than 50 million people worldwide. In addition, its socioeconomic consequences were huge. "Spanish flu", as the infection was dubbed, hit different agegroups, displaying a so-called "W-trend", typically with two spikes in children and the elderly. However, healthy young adults were also affected. In order to avoid alarming the public, several local health authorities refused to reveal the numbers of people affected and deaths. Consequently, it was very difficult to assess the impact of the disease at the time. Although official communications issued by health authorities worldwide expressed certainty about the etiology of the infection, in laboratories it was not always possible to isolate the famous Pfeiffer's bacillus, which was, at that time, deemed to be the cause of influenza. The first official preventive actions were implemented in August 1918; these included the obligatory notification of suspected cases and the surveillance of communities such as day-schools, boarding schools and barracks. Identifying suspected cases through surveillance, and voluntary and/or mandatory quarantine or isolation, enabled the spread of Spanish flu to be curbed. At that time, these public health measures were the only effective weapons against the disease, as no vaccines or antivirals were available. Virological and bacteriological analysis of preserved samples from infected soldiers and other young people who died during the pandemic period is a major step toward a better understanding of this pandemic and of how to prepare for future pandemics

L'astragalo di Dario

After hunting, the king of Persians Darius I gets off a horse in a quite rough way and gets a sprain in which the astragalus becomes dislocated. The wise Egyptian physicians on duty at his court cannot heal the shooting pain which keeps him awake for a week. By chance, Democedes, the famous physician from Croton, happens to be at Persian court as a slave and Darius, finding out about it, doesn’t esitate to commit himself to his healing which turns out to be providential. This tale, which in its richest and most interesting version came to us thanks to the Greek historian Herodotus, allows not only a reflection upon the ancient therapeutical approaches to the sprains, thanks to the comparison with Hippocratic treaties on fractures and articulations, but also some anatomical considerations on the interaction between astragalus and the articulations it is connected with

Maschile e femminile nella trasmissione dei caratteri ereditari. Da Atene a Sparta

The selection of individuals through eugenic criteria was a widespread habit in the ancient Greek society, especially at Sparta where εὐγενέτης is a very meaningful word: it expresses both the social high rank of Spartiates and the physical perfection the community requires. Not surprisingly the same term referred to animals means “well breeding”. However, though in Athens the patrilineal transfer of hereditary characters has a higher juridical value, according to the oldest embryological beliefs, at Sparta woman’s role in the eugenic determination of the race turns out to be more active and not limited to that of mere container. Thereafter, came the necessity of physical training and of a diet during pregnancy to offer the community a healthy birth. As the male trains himself for war and his glory consists in returning victorious or dying for his fatherland, similarly also the Spartan woman prepares to her utmost challenge, that is: her delivery, which may even lead to death

Children in Greco-Roman society. Age, development, work and nosological relevance. A historico-medical perspective

The definition of childhood in historical studies is as recent a problem as the attention devoted by scholars to this age group. A reflection on the nomenclature used in Greek and Latin literary, epigraphic, legal and properly medical sources and the comparison with paleopathological studies allows us to interpret the historical perception of childhood in terms of incompleteness. In the Hippocratic and Galenic tradition this incompleteness unites children to fragile and marginalized categories, namely women and the elderly, but above all it does not recognize their specific diseases, delaying the birth of pediatrics for centuries

Electrotherapy in the treatment of patients affected by rabies: Experiments conducted at the maggiore hospital of Milan in 1865,Elektroterapija u lijeenju pacijenata zaraenih bjesnoom: Pokusi provoeni u bolnici maggiore u milanu tijekom 1865. godine

During the nineteenth century, the scientific context of rabies treatment was weak due to the lack of the literature on specific nosology of the rabies disease, and unspecific and ineffective therapy approaches. Electrotherapy already represented an important therapeutic approach for nervous system diseases, although not specifically for rabies. In the present paper, the authors discuss the use of electrotherapy in the treatment of humans affected by rabies in an experimental study conducted at the Maggiore Hospital of Milan, with the aim of establishing the discovery of a possible specific therapy. By analyzing the printed scientific sources available in the Braidense Library of Milan, the authors describe four experiments conducted on patients of different ages. Symptoms and effects both during and after the electrotherapy are also highlighted. The experiments demonstrated that electricity is not an effective therapy in the treatment of rabies, being rather able to cause serious functional and organic alterations in all the patients. Analyzing the Milanese experiments, the authors reported specific Italian history of a scientific and medical approach to rabies at the end of the 18th century, which led to the promotion of health education, reinforced prevention strategies and opened the way to the vaccination era

Encouraging versatile thinking in algebra using the computer

In this article we formulate and analyse some of the obstacles to understanding the notion of a variable, and the use and meaning of algebraic notation, and report empirical evidence to support the hypothesis that an approach using the computer will be more successful in overcoming these obstacles. The computer approach is formulated within a wider framework ofversatile thinking in which global, holistic processing complements local, sequential processing. This is done through a combination of programming in BASIC, physical activities which simulate computer storage and manipulation of variables, and specific software which evaluates expressions in standard mathematical notation. The software is designed to enable the user to explore examples and non-examples of a concept, in this case equivalent and non-equivalent expressions. We call such a piece of software ageneric organizer because if offers examples and non-examples which may be seen not just in specific terms, but as typical, or generic, examples of the algebraic processes, assisting the pupil in the difficult task of abstracting the more general concept which they represent. Empirical evidence from several related studies shows that such an approach significantly improves the understanding of higher order concepts in algebra, and that any initial loss in manipulative facility through lack of practice is more than made up at a later stage

Commentary on Raphael's The Transfiguration

Historical sources about Raphael’s death provide different hypotheses about its cause. Continuous fever is the only symptom described. Raphael’s lucidity in managing his last affairs exclude syphilis, made widespread by the French army. The same applies to malaria, which was endemic in Rome. Not even the reference to bloodletting helps us,1 as it was a longstanding therapy to reduce fever. The most prudent hypothesis is an infectious diseas

The history of tuberculosis: The social role of sanatoria for the treatment of tuberculosis in Italy between the end of the 19th century and the middle of the 20th

Since ancient times, the most frequently prescribed remedy for the treatment of tuberculosis was a stay in a temperate climate. From the middle of the 19th century to the middle of the 20th, Europe saw the development of sanatoria, where patients were able to benefit from outdoor walks, physical exercise and a balanced diet. Moreover, the institutionalisation and isolation of patients deemed to be contagious remains one of the most efficacious measures for the control of this type of infection. The first sanatorium opened in Germany in 1854, while in Italy the earliest experiments were conducted at the beginning of the 20th century. At that time, it was widely believed in Italy that pulmonary tuberculosis could improve in a marine climate. By contrast, the scholar Biagio Castaldi described the salubrious effects of mountain air and documented a lower incidence of tuberculosis among mountain populations, which supported the hypothesis of a hereditary predisposition to the disease. In 1898, several local committees (Siena, Pisa, Padua) were founded to fight tuberculosis. The following year, these gave rise to the Lega Italiana (Italian League) under the patronage of the King of Italy, which helped to promote state intervention in the building of sanatoria. The pioneer of the institution of dedicated facilities for the treatment of tuberculosis was Edoardo Maragliano in Genoa in 1896. A few years later, in 1900, the first specialised hospital, with a capacity of 100 beds, was built in Budrio in a non-mountainous area, the aim being to treat patients within their habitual climatic environment. In the following years, institutes were built in Bologna, Livorno, Rome, Turin and Venice. A large sanatorium for the treatment of working-class patients was constructed in Valtellina by the fascist government at the beginning of the century, in the wake of studies by Eugenio Morelli on the climatic conditions of the pine woods in Sortenna di Sondalo, which he deemed to be ideal. In December 1916, the Italian Red Cross inaugurated the first military sanatorium in the \u201cLuigi Merello\u201d maritime hospice in Bergeggi (SV) to treat soldiers affected by curable tuberculosis. In 1919, a specific law mandated a 10-fold increase in funding for the construction of dispensaries and sanatoria. As a result, the Provincial Anti-tuberculosis Committees were transformed into Consortiums of municipal and provincial authorities and anti-TB associations, with the aim of coordinating the action to be undertaken. In 1927, the constitution of an Anti-tuberculosis Consortium in every province became a legal obligation. Despite this growth in social and healthcare measures, tuberculosis in Italy continued to constitute a major public health problem until the advent of antibiotics in the 1950s. Until that time, the sanatorium played a leading role in the treatment of tuberculosis in Italy, as in the rest of Europe

Detecting event-related recurrences by symbolic analysis: Applications to human language processing

Quasistationarity is ubiquitous in complex dynamical systems. In brain dynamics there is ample evidence that event-related potentials reflect such quasistationary states. In order to detect them from time series, several segmentation techniques have been proposed. In this study we elaborate a recent approach for detecting quasistationary states as recurrence domains by means of recurrence analysis and subsequent symbolisation methods. As a result, recurrence domains are obtained as partition cells that can be further aligned and unified for different realisations. We address two pertinent problems of contemporary recurrence analysis and present possible solutions for them.Comment: 24 pages, 6 figures. Draft version to appear in Proc Royal Soc